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  • The Reverser II
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    The Reverser II
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The Reverser II

Advanced Renewal Serum for Experienced Retinoid & Resilient Skin

$150.00
$150.00
Shipping calculated at checkout.

Dr. Colombo's Clinical Promise

"Once your skin is comfortable with a retinoid, this is where I take patients next. It's the same well-tolerated HPR, at a strength built to drive serious collagen renewal — my go-to for firming, refining pores, and lifting mature and resilient skin."

Dr. Morgana Colombo, MD · Board-Certified Dermatologist · Reston, VA

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Receive a $100 credit toward any non-subscription product when you sign up for a 12 month subscription. Check your email for credit code after purchase.
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A gentle retinoid acid ester HPR and niacinamide ester serum.

🛡 30-Day Skin Improvement Guarantee. If you don't see a visible difference in 30 days of consistent use, Dr. Colombo will personally make it right — full refund or exchange, no hoops.

⬆ Higher potency, still surprisingly gentle. A stronger dose of the same HPR retinoid that drives serious collagen renewal — without the redness and peeling of prescription tretinoin.

⚕️ Dr. Colombo's pick for resilient skin. Her go-to for experienced retinoid users and thicker, oilier skin ready for maximum anti-aging results.

Suitable for all skin types except extremely sensitive skin.

90-day Money Back Guarantee  · Physician Formulated · Free Shipping

The Reverser II
The Reverser II

  • 5★ Across All Reviews

  • 4–6wk To Smoother Texture

  • 8–12wk To Firmer, Lifted Skin

  • HPR+ Advanced Strength

You've outgrown your starter retinoid.

Once your skin has adapted to a retinoid, a gentle dose stops moving the needle. Collagen renewal plateaus, and the firming and pore-refining results you want need more horsepower than a beginner formula can deliver.

The Reverser II is the advanced step up. It's built on the same Hydroxypinacolone Retinoate (HPR) — a next-generation retinoic-acid ester that binds directly to the skin's retinoid receptors — but at a higher potency engineered for deeper collagen stimulation. Buffered with niacinamide, it delivers results comparable to prescription tretinoin while staying far gentler. Ideal for experienced users and thicker, oilier, more resilient skin.

Comparable to prescription tretinoin · Niacinamide-buffered · Best for experienced users & oilier skin

What It Does

Advanced renewal your skin is ready for.

  • 01

    Smooths Fine Lines

    A higher dose of HPR accelerates cell turnover and collagen production — visibly softening fine lines, wrinkles, and crepey texture for skin that's already retinoid-adapted.

  • 02

    Refines Pores

    Deeper renewal clears and tightens the look of enlarged pores — especially effective on the thicker, oilier skin this formula was designed for.

  • 03

    Firms & Lifts

    By driving serious collagen stimulation, The Reverser II makes skin look tighter, firmer, and more lifted — Dr. Colombo's go-to collagen booster for mature skin.

  • 04

    Evens Tone

    Accelerated turnover plus a stabilized vitamin C ester fade the look of uneven tone, sun damage, and dullness for a brighter, more radiant complexion.

  • 05

    Stronger, Still Gentle

    Niacinamide and bisabolol buffer the higher-potency retinoid — so you get advanced results without the burning and peeling of prescription tretinoin.

  • 06

    Year-Round Use

    Lightweight and fast-absorbing with a non-greasy finish — a go-to retinoid resilient skin can use consistently, all year, without downtime.

More potency, still buffered for comfort.

Hydroxypinacolone Retinoate

A next-generation retinoic-acid ester, here at advanced strength. It binds directly to retinoid receptors to drive deeper cell turnover and collagen production — potency comparable to prescription tretinoin, with far less irritation. The active that makes serious renewal tolerable.

Niacinamide (Vitamin B3)

Strengthens the skin barrier, calms redness, and regulates oil — buffering the higher-strength retinoid so even thicker, oilier skin renews without flaking or irritation.

Tetrahexyldecyl Ascorbate

A stable, oil-soluble vitamin C ester that penetrates deeply to brighten tone, defend against free-radical damage, and amplify the renewing effect of the retinoid.

Bisabolol

A soothing extract derived from chamomile that reduces the look of redness and irritation — keeping skin calm as it works at a higher intensity.

Tocopherol (Vitamin E)

A nourishing antioxidant that protects the barrier and works alongside vitamin C to defend skin from daily oxidative stress.

Silicone Glide Base

A lightweight ethyl trisiloxane and dimethicone base that absorbs quickly to a smooth, non-greasy finish — light enough that reviewers reach for it nightly, year-round.

The same well-tolerated HPR retinoid Dr. Colombo formulates for sensitive skin — concentrated for experienced users and resilient skin ready for maximum collagen renewal.

HOW TO USE

Build up. Then make it nightly.


01 CLEANSE & DRY

Begin with a gentle cleanser in the evening. Pat skin completely dry before applying — damp skin can intensify any retinoid.


02 START EVERY OTHER NIGHT

Smooth a small amount over the face every other night to start. As your skin adjusts, build toward nightly use — the progression most of our reviewers followed to daily use.


03 FOLLOW WITH THE HYDRATOR

Layer The Hydrator on top to lock in moisture and minimize irritation — Dr. Colombo's recommended pairing with The Reverser II.


04 SPF EVERY MORNING

Retinoids increase sun sensitivity. Always follow with The Clear or Dewy Tint Sunscreen to protect — and preserve — every result.

Best for thicker, oilier, or retinoid-experienced skin.

If you're new to retinoids or have sensitive skin, start with The Reverser I and graduate to II once your skin is comfortable. Suitable for all skin types except extremely sensitive skin.

Full Ingredients

Cyclopentasiloxane, Caprylic/Capric triglyceride, Disiloxane, Polysilicone-11, Glyceryl oleate, Myristyl nicotinate, Hydroxypinacolone retinoate, Bisabolol, Tetrahexyldecyl ascorbate and Tocopherol

CUSTOMER REVIEWS

Real Reviews. Real Results.

Everything you need to know before buying.

What type of retinoid is in The Reverser II?

The Reverser II uses Hydroxypinacolone Retinoate (HPR), the same stable, well-tolerated retinoic-acid ester as The Reverser I — but at an advanced strength. It's comparable in potency and efficacy to prescription tretinoin while causing significantly less irritation, making it ideal for experienced retinoid users and resilient skin.

Should I choose Reverser I or Reverser II?

The Reverser II is best for experienced retinoid users, thicker or oilier skin, and anyone seeking stronger anti-aging results. If you've never used a retinoid, have sensitive skin, or retinol has irritated you before, start with The Reverser I and graduate to II once your skin is comfortable.

Is HPR really less irritating than retinol?

Yes. HPR binds directly to the skin's retinoid receptors without the conversion step that drives much of retinol's irritation, so it causes less redness and peeling. Even at the higher strength of The Reverser II, reviewers describe it as effective but not irritating — many work up to nightly use.

When will I see results?

Most users notice smoother texture within 4–6 weeks of consistent use, with one reviewer reporting significant improvement in about a month. Firming, pore refinement, and fine-line softening continue to develop over 8–12 weeks. Brightness and glow often appear earlier.

What if it doesn't work for my skin?

We offer a 30-day skin improvement guarantee. If you don't see a visible difference with consistent use, Dr. Colombo will personally make it right — full refund or exchange, no questions asked and no hoops to jump through.

How should I work it into my routine?

Use it in the evening, starting every other night and building toward nightly as tolerated. Follow with The Hydrator to lock in moisture and minimize irritation, and always use sunscreen each morning. The Reverser II is suitable for all skin types except extremely sensitive skin.

How does the subscription work?

You can subscribe for delivery every 3 months (15% off, $127.50), 6 months (20% off, $120), or 12 months (25% off, $112.50). The 12-month subscription also includes a $100 credit toward any non-subscription Vidaderma product — your code is emailed after purchase. Subscriptions auto-renew and can be skipped or cancelled anytime.

  • The Reverser II
  • The Reverser II
    The Reverser II
1 2

Ready for more than a starter retinoid.

The gentle, fragrance-free cleanse that calms as it works — formulated by the dermatologist who treats sensitive and rosacea-prone skin every day in her practice.

90-Day Money Back Guarantee · Physician Formulated · Free Shipping

The Reverser II
The Reverser II