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Dr. Colombo’s Protocol

The regimen Dr. Colombo uses on her own skin—and recommends to patients who want the most comprehensive at-home longevity routine.

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Dr. Colombo's Clinical Promise

"I'm not the only dermatologist who runs a personal protocol. I might be one of the few who'll tell you exactly what it is. This is mine, and it's the regimen I recommend when a patient asks me, 'What would you do if you were me?' — because in many cases the answer is genuinely this."

Dr. Morgana Colombo, MD · Board-Certified Dermatologist · Reston, VA

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Care for your skin like a Dermatologist! Dr. Colombo’s Protocol is the personal regimen that she uses every day, built for all around skin health and longevity.

HOW TO USE

Morning (AM)
The Wash: A gentle, foamy cleanser designed to gently cleanse all skin types, particularly sensitive and redness-prone skin.
The Hydrator: A lightweight hydrator infused with hyaluronic acid and ceramides, universally friendly for all skin types.
The Dewy Tint Sunscreen: A broad-spectrum SPF 40 tinted mineral sunscreen that acts as a foundation primer, provides hydration, and blurs minor imperfections.

Night (PM)
The Wash: A gentle, foamy cleanser designed to gently cleanse all skin types, particularly sensitive and redness-prone skin.
The Reverser I: A gentle retinoid acid ester HPR and niacinamide ester serum. Use two nights a week.
The PhytoEstro Age Eraser: An age-defying multi-action, synergistic blend of hyaluronic acid, peptides, antioxidants, plant based growth factor kinetin along with phytoestrogen soy isoflavones that work to revitalize, renew and deeply hydrate estrogen deficient skin.
The Eye Neck Complex: A comprehensive eye and neck treatment infused with antioxidants, peptides, the HPR retinoid and the plant based growth factor kinetin designed to reduce the appearance of fine lines, wrinkles, laxity, and provide hydration and a brighter appearance.

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The protocol I use on my own face.

This is the regimen I built for myself over years of dermatology practice — refined through what I've seen work for my patients, what's failed, and what the most recent evidence supports. It's not the most expensive routine I could put together. It's the one that delivers the most measurable longevity per product, with no redundancy and no missing steps.

Six products across two routines. A gentle retinoid every other night, because that's the schedule that delivers the most collagen support with the least cumulative irritation. A hormone-aware cream at night that addresses the structural changes most anti-aging products ignore. And a dedicated eye and neck cream — because those two areas show age first, and the face-cream-on-the-neck approach simply doesn't work. This is what I do. This is what works.

Why Regimens Outperform Single Products
The science behind the regimen.

01
Every other night, not every night
Retinoid nightly produces the same skin you'd have at every-other-night use in most patients — but with more cumulative irritation, more downtime, and worse adherence. The off-nights aren't lost; they're recovery.
02
Eye and neck age 5× faster
Both areas have thinner skin, fewer sebaceous glands, and more movement. They show aging at fractional time scales compared to the rest of the face. A dedicated cream addresses that directly.
03
Multi-active layering at PM
On retinoid nights, the phytoestrogen-supported cream goes on top — buffering the retinoid while delivering its own actives. This is why you can use a retinoid this consistently without barrier compromise.
04
Comprehensive, not maximal
This protocol is what's measurably useful — not what's possible. There are products I could add. I don't, because the marginal benefit drops off sharply past this point and the risk of barrier compromise from product layering rises.

The Protocol · Two Routines

Each step, and why it's there.

MORNING REGIMEN

STEP 1 Cleanse: THE WASH

""Gentle cleanse to start. Even a healthy barrier benefits from a non-stripping wash — and any aggressive cleansing in the morning undoes the overnight repair work."
- Dr. Colombo

Step 2 Hydrate: THE HYDRATOR

"Hyaluronic acid and ceramides for daytime hydration that holds. The Hydrator is lightweight enough to go under sunscreen without pilling, and substantive enough that skin stays comfortable through the day."
- Dr. Colombo

Step 3 Protect: THE DEWY TINT SUNSCREEN

"14% zinc with iron oxide for visible-light protection. SPF is the single most important anti-aging product I use — and the dewy tint replaces foundation on most days, which means it actually gets applied generously enough to matter."
- Dr. Colombo

EVENING REGIMEN

STEP 1 Cleanse: THE WASH

"Remove the day's sunscreen and pollution. One pass is enough — what most patients call a 'second cleanse' is just over-cleansing in disguise."
- Dr. Colombo

Step 2 Renew (Every Other Night): THE REVERSER I

"Gentle HPR retinoid for collagen support and cell turnover. The every-other-night schedule is deliberate — it delivers the same long-term results as nightly use with substantially less cumulative irritation and barrier disruption. The off-nights are when repair happens."
- Dr. Colombo

Step 3 Treat & Restore: THE PHYTOESTRO AGE ERASER

"On retinoid nights, this goes on after the serum to buffer and treat. On off nights, it's the entire treatment layer. Phytoestrogen-supported peptides, ceramides, and antioxidants — built specifically for skin in or approaching the hormonal transition."
- Dr. Colombo

Step 4 Eye & Neck: THE EYE NECK COMPLEX

"The two areas that show age first. Thinner skin, fewer oil glands, more constant movement. A dedicated cream isn't optional after 40 — and the face can look ten years younger than the neck without one."
- Dr. Colombo

WHAT TO EXPECT

The protocol becomes maintenance, and the results compound. Patients on this regimen for two years or more consistently look measurably younger than peers.

Full Ingredients

THE WASH: Water, Decyl glucoside, Sodium cocosulfate, Disodium laurylsulfosuccinate, Glycereth-26, Disodium PEG-12 dimethicone sulfosuccinate, Lauryl methyl gluceth-10 hydroxypropyldimonium chloride, Glycerin, PEG-40 Hydrogenated castor oil, Evodia rutaecarpa fruit extract, Dipotassium glycyrrhizate, Povidone, Citric acid, 1,2 Hexanediol, Caprylyl glycol, Bisabolol, Ginger root extract, Allantoin, Potassium sorbate and Edetate tetrasodium

THE HYDRATOR: Water, Sodium hyaluronate crosspolymer, Squalane, Glycerin, Ceteareth-25, Cetyl Alcohol, Behenic acid, Cholesterol, Ceramide NP, Ceramide NS, Ceramide EOS, Ceramide EOP, Ceramide AP, Caprooyl phytosphingosine, Caprooyl sphingosine, Isopropyl palmitate, Petrolatum, Pentylene glycol, Glyceryl stearate, Dimethicone, Caprylyl glycol,1,2 Hexanediol, Acrylates /C10-30 Alkyl acrylate crosspolymer, Triethanolamine, Allantoin, Potassium sorbate and Disodium EDTA

THE DEWY TINT SUNSCREEN: Active Ingredients: Zinc oxide, 14%. Inactive Ingredients: Alumina, Argania spinosa kernel oil, Bisabolol, Brassica campestris (Rapeseed) sterols, Caprylyl methicone, Cetylhydroxy-proline palmitamide, Cyclopentasiloxane, Dimethicone crosspolymer, Dimethicone/Vinyl dimethicone crosspolymer, Dimethiconol, Ethyl ferulate, Hexyldecanol, Hydrogen dimethicone, Iron oxides, Lauryl PEG/PPG-18/18 methicone, Silica, Squalane, Stearic acid, Tetrahexyldecyl ascorbate, Tocopheryl acetate, Triethoxycaprylylsilane, Trihydroxystearin and Trimethylsiloxysilicate

THE AGE ERASER: Water/Aqua, Caprylic Capric triglyceride, Hydrogenated phosphatidylcholine, Pentylene glycol, Glycerin, Butyrospermum Parkii (Shea) butter, Squalane, Ceramide NP, Sodium hyaluronate crosspolymer, Tetrahexyldecyl ascorbate, Isopropyl palmitate, Ethyl trisiloxane, Petrolatum, Niacinamide, Butylene glycol, Carbomer, Palmitoyl oligopeptide, Palmitoyl tetrapeptide-7, Dimethylacrylamide/Acrylic acid/Polystyrene ethyl methacrylate copolymer, Oryza sativa (Rice) bran extract, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Tocopherol, Sodium oleate, Oligopeptide-68, Acetyl hexapeptide-37, Feruloyl soy glycerides, Kinetin 1,2-Hexanediol and Caprylyl glycol

THE REVERSER I: Ethyl trisiloxane, Dimethicone, Dimethicone/Vinyl dimethicone crosspolymer, Caprylic/capric triglyceride, Myristyl nicotinate, Glyceryl oleate, Hydroxypinacolone retinoate, Bisabolol, Tetrahexyldecyl ascorbate and Tocopherol

THE EYE NECK COMPLEX: Water, Acetyl hexapeptide-8, Butylene glycol, Cetearyl alcohol, Hexyldecanol, Bisabolol, Cetyl hydroxy- proline palmitate, Stearic acid, Brassica campestris (Rapeseed) sterols, Tetrahexyldecyl ascorbate, Sodium lactate, Glycerin, Isododecane, Isopropyl palmitate, Glyceryl stearate, Palmitoyl oligopeptide, Palmitoyl tetrapeptide-7, Tocopheryl acetate, Niacinamide, Petrolatum, Dextran, Caprooyl tetrapeptide-3, Evodia rutaecarpa fruit extract, L-Ergothioneine, Dimethicone, Magnesium aluminum silicate, PEG-40 stearate, Feruloyl soy glycerides, Sodium hyaluronate, 1,2 Hexanediol, Caprylyl glycol, Potassium sorbate, Xanthan gum, Allantoin, Pentylene glycol, Polysorbate-20, Ceteareth-20, Hydroxypinacolone retinoate, 3-Aminopropane sulfonic acid, Calcium hydroxymethionine, Hydroxyethyl cellulose, Kinetin, Edetate disodium and BHT

Frequently Asked Questions, Answered

Should I use the retinoid more often than every other night?

Most patients see no additional benefit from nightly use over every-other-night, but they do see more irritation. Stay at every-other-night unless your dermatologist specifically advises otherwise. Some patients build to nightly after several months; many never do, and never need to.

What if I have very sensitive skin?

Drop the retinoid to twice a week instead of every other night. Use The Hydrator on the off-nights if the Phytoestro Age Eraser feels too active. The Sensitive Skin Protocol may be a better starting point — you can graduate to this one once your barrier is consistent.

Is this Dr. Colombo's exact personal routine?

Yes. This is the regimen she uses herself and refines as her practice and the evidence evolve. The specific products are formulated for the protocol; the schedule reflects what she's found most patients can actually maintain.

Should I add a vitamin C serum?

Optional. Many patients on this protocol layer The Booster in the morning between The Hydrator and the sunscreen for additional antioxidant defense. It's the single best optional add-on, and the most common one Dr. Colombo's patients ask about.

What if I'm not in menopause? Is the Phytoestro Age Eraser still right?

Yes. It's built for menopausal skin but works well as a comprehensive anti-aging cream for any maturing skin from late 30s onward. If you prefer a less rich formula, The Age Eraser is the alternative, and Dr. Colombo uses it on patients who want similar mechanisms in a lighter weight.

Can I do this regimen while pregnant?

Pause the retinoid (Reverser I) for pregnancy and nursing. The rest of the protocol is generally safe, but confirm with your obstetrician. After nursing, the retinoid reintroduces easily; many patients pick up exactly where they left off.

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The complete protocol, at a protocol price.

Developed by Dr. Morgana Colombo, board-certified dermatologist. Built on the evidence — and the regimen logic that single products can't replicate.

Free shipping · Subscribe and save · Includes the complete AM & PM regimens above